Mathews Journal of Nutrition & Dietetics


Previous Issues Volume 3, Issue 1 - 2018

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Prevalence of Specific IgG to Food Antigens in Bulgarian IBS Patients: A Preliminary Study

Tsvetelina Velikova1*, Iskra Altankova1, Milena Peruhova2, Antoaneta Mihova1, Alexander Kukov3, Viktoriya Georgieva2 , Nonka Yurukova2, Gergana Mizgova4, Tsanka Mehandzhiyska-Marinova4,6, Velislava Terzieva1, Galina Zhelezova5, Ludmila Ivanova6

1 Institute for Research and Development of the Sustainable Ecosystems (IRES), Srebrnjak 59, 10000 Zagreb, Croatia.
2 University Hospital Centre Zagreb, Department of Oncology, Kispaticeva 12, 10000 Zagreb, Croatia.
3 Aviva Medical Center, Nemetova 2, 10000 Zagreb, Croatia.
4 University of Zagreb, School of Dental Medicine, Gunduliceva
5 10000 Zagreb, Croatia. 5 RUDN University, Miklukho-Maklaya str.
6 Moscow 117198, Russia. 6 University Psychiatric Hospital Vrapce, Bolnicka cesta 32, 10090 Zagreb, Croatia

Corresponding Author: Tsvetelina Veselinova Velikova, Clinical Immunology, University Hospital 'Lozenetz', Kozyak 1 Str., 1407 Sofia, Bulgaria, Tel: 00359883306049; E-Mail[email protected]

Received Date: 06 Nov 2018  
Accepted Date: 15 Nov 2018  
Published Date: 20 Nov 2018

Copyright © 2018 Velikova TV

Citation:Velikova TV, Altankova I, Peruhova M, Mihova A, et al. (2018). Prevalence of Specific IgG to Food Antigens in Bulgarian IBS Patients: A Preliminary Study. Mathews J Nutr Diet. 3(1): 017.



Since food intolerance in IBS patients may be mediated by IgG-dependent mechanisms, we aimed to investigate the prevalence of specific IgG antibodies to a panel of common food antigens in a Bulgarian cohort of IBS patients. We enrolled fifteen patients with IBS at mean age 36-10 years, diagnosed according to the Rome IV criteria. Specific IgG to food antigens in serum samples were assessed by IgG Screen Nutritional 24 ELISA. In our IBS patients we found that 40% have significant levels (> 3.51 U/ml) of specific IgG to egg white, 53,3% to cow milk, 33,3% to wheat, 20% to orange, 33,3%, to kiwi, 20% to tomato, 26,7% to garlic, 26,8% to hazelnut. Moreover, we found that 6,7 - 13,3% of IBS patients have IgG to egg white, cow milk, wheat, kiwi and hazelnut above 50 U/ml. We found also correlations of the specific IgG antibodies of some pairs of food antigens (mostly for codfish, wheat and other grains) where the correlations were assessed as moderate to strong. In conclusion, the serological determination of specific antibodies (IgG) against different food antigens may be beneficial to all individuals who are suffering from food intolerance, including patients with IBS. However, we should use these test with caution.


Keywords: IBS; Food Intolerance; Food Antigen; Specific IgG Antibodies; IgG-Mediated Hyperreactivity.

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