Cyclodextrins: Development of Systems for Constant and Long-Term Release of Bioactive Compounds

¹University of Life Sciences “King Mihai I” from Timisoara, Timisoara, Romania

²”Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania

³Drug Data Analysis Center, Computer Chemistry and the Internet of Medical Things, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania

*Corresponding author: Monica Butnariu, University of Life Sciences “King Mihai I” from Timisoara, Timisoara, Romania, E-mail: [email protected]

Received Date: May 28, 2026

Published Date: June 18, 2026

Citation: Iozsa E, et al. (2026). Cyclodextrins: Development of Systems for Constant and Long-Term Release of Bioactive Compounds. Mathews J Nutr Diet. 9(1):46.

Copyrights: Iozsa E, et al. © (2026).

ABSTRACT

Cyclodextrins are cyclic oligosaccharides obtained by enzymatic degradation of starch. Due to their unique truncated cone shape, they have a hydrophobic internal cavity (which attracts fats) and a hydrophilic external surface (soluble in water). Cyclodextrins are cyclic oligomers obtained from the enzymatic degradation of starch. Cyclodextrins have a special structure composed of a hydrophobic cavity in which various poorly soluble medicinal substances can be included to form water-soluble inclusion complexes. This characteristic is at the origin of many uses of different types of cyclodextrins and they find their applicability in numerous fields: pharmaceutical and cosmetic industry, biotechnology, nanotechnology, medicine, food industry, textile industry, etc. The formulation of a cyclodextrin–drug complex depends on their chemical structure and physicochemical properties. In the pharmaceutical industry, cyclodextrins are frequently used, mainly due to their ability to increase the solubility of a poorly soluble drug substance without changing its physicochemical and biological properties.

Keywords: Drug Solubility, Cyclodextrins, Inclusion Compounds, Hydrophobic Internal Cavity, Enzymatic Degradation.