Mathews Journal of Dermatology

2474-6894

Previous Issues Volume 2, Issue 1 - 2017

Review Article Full-Text  PDF  

Insights into Dermatological Applications and Cutaneous Toxicities of Bleomycin

Ahmed M. Kabel1,2*, Fatma M. Moharm3,4

1Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.

2Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.

3Al Maha Care Clinics, Mecca, Saudi Arabia.

4Dermatology Specialist, Ministry of Health, Egypt.

Corresponding Author: Ahmed M. Kabel, Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt, 
Tel: +966564833526; E-Mail: drakabel@gmail.com

Received Date: 07 Dec 2016   

Accepted Date: 23 Feb 2017   

Published Date: 24 Feb 2017

Copyright © 2017 Kabel AM

Citation: Kabel AM and Moharm FM. (2017). Insights into Dermatological Applications and Cutaneous Toxicities of Bleomycin. Mathews J  Dermatol. 2(1): 010

 

ABSTRACT

Bleomycin is a chemotherapeutic agent used for treatment of many types of tumors including lymphomas, testicular cancer and breast cancer. Its cytotoxic effect may be attributed to its interaction with O2 and Fe2+ leading to scission of DNA. Its systemic application may be associated with serious pulmonary fibrosis. It may be used by intralesional injection for management of keloids, hypertrophic scars, cutaneous warts, hemangiomas, cutaneous malignancies, cutaneous leishmaniasis and condyloma accuminata. However, its use may lead to significant dermatologic toxicities including scratch dermatitis, Raynaud's phenomenon, hyperpigmentation, fibrosis, gangrene, neutrophilic eccrine hidradenitis, alopecia areata, oedema and nail changes.

Keywords

Bleomycin; Dermatology; Applications; Toxicity; Skin


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