Cytokine-induced Neurogenesis for the Treatment of IVF-induced ASD

¹Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan

²Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan

³Livant Neurorecovery Center, Guadalajara, Mexico

*Corresponding Author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan & Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan, Email: [email protected]

Received Date: March 11, 2026

Published Date: March 25, 2026

Citation: Shirasawa T, et al. (2026). Cytokine-induced Neurogenesis for the Treatment of IVF-induced ASD. Mathews J Case Rep. 11(1):219.

Copyrights: Shirasawa T, et al. © (2026).

ABSTRACT

In this case report, three cases of autism spectrum disorder (ASD) with a potential etiology of in vitro fertilization were presented. To the best of our knowledge, this is the first report suggesting that epigenetic gene modifications due to in vitro fertilization play an important role in the pathology of ASD. Furthermore, we demonstrated that cytokine-induced neurogenesis can improve ASD symptoms in all three cases presented in this paper. This innovative therapeutic approach for treating ASD has the potential to be extrapolated to other forms of ASD with different etiologies. An imbalance between GABAergic inhibitory neurons and glutamatergic excitatory neurons plays an important role in the etiology of ASD. This imbalance has been linked to the emergence of ASD symptoms, and the alleviation of these symptoms has been associated with cytokine-induced neurogenesis. Written informed consent was obtained from the patients.

Keywords: IVF, Epigenesis, Cytokine, Neurogenesis, ASD.