Mathews Journal of Case Reports


Previous Issues Volume 8, Issue 3 - 2023

Cytokine-induced Neurogenesis Can Reverse Cognitive Decline in Alzheimer’s Disease

Takuji Shirasawa1*, Luis Carlos Aguilar Cobos2

1Ochanomizu Health and Longevity Clinic, Tokyo, Japan

2Livant Neurorecovery Center, Guadalajara, Mexico

*Corresponding author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, Tokyo, Japan; Email: [email protected]

Received Date: March 9, 2023

Publication Date: March 21, 2023

Citation: Shirasawa T, et al. (2023). Cytokine-induced Neurogenesis Can Reverse Cognitive Decline in Alzheimer’s Disease. Mathews J Case Rep. 8(3):97.

Copyright: Shirasawa T, et al. © (2023)


Alzheimer’s disease (AD) is a progressive neurodegenerative disease for which no curative treatment has yet been established. We applied cytokine-induced neurogenesis treatment to a 69-year-old female AD patient carrying APOE ε4/ε4 alleles to regenerate residual neuronal stem cells, resulting in the successful regeneration of the atrophied cerebral cortex and hippocampus associated with improved cognitive function and the resolution of electrophysiological abnormalities. To the best of our knowledge, this is the first case report demonstrating that cytokine-induced neurogenesis can reverse cognitive decline due to AD.

Keywords: Alzheimer’s disease (AD), APOE, Cytokine, Neurogenesis, Cognitive decline

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