Alzheimer’s Disease with Carotid Intraluminal Findings and Rheumatoid Arthritis–Like Symptoms: A Case Report

¹Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan

²Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan

³Livant Neurorecovery Center, Guadalajara, Mexico

*Corresponding Author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan & Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan, E-mail: [email protected]

Received Date: May 30, 2026

Published Date: June 22, 2026

Citation: Shirasawa T, et al. (2026). Alzheimer’s Disease with Carotid Intraluminal Findings and Rheumatoid Arthritis–Like Symptoms: A Case Report. Mathews J Case Rep. 11(3):228.

Copyrights: Shirasawa T, et al. © (2026).

ABSTRACT

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which no curative therapy has been established. In this case report, a 79-year-old female patient with the APOE ε4/ε4 genotype presented at our clinic with a complaint of memory impairment. Initial evaluation, including magnetic resonance imaging (MRI) and electroencephalography (EEG), suggested AD with concomitant carotid intraluminal findings and rheumatoid arthritis–like symptoms. The patient subsequently received cytokine-based therapy in combination with a proteolytic treatment protocol. During follow-up, interval changes were observed in hippocampal morphology, carotid intraluminal findings, and rheumatoid arthritis–like symptoms. Although causal inferences cannot be drawn from a single case report, this report documents multimodal clinical and imaging changes in a patient with complex dementia-associated comorbid features.

Keywords: Alzheimer’s Disease, Case Report, Carotid Intraluminal Findings, Rheumatoid Arthritis–Like Symptoms, Cytokine-Based Therapy.