Exploring The Role of Iron Accumulation and Muscle Parameters as Potential Risk Factors for Sarcopenia

¹Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, P.R. China

²School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, China

³Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, China

*Corresponding author: Dr. Zhao Guo-Yang, Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu Province-212013, China, Phone: 18252583559, ORCID ID: 0000-0002-6980-9997, Email: [email protected]

Received Date: April 26, 2025

Published Date: June 23, 2025

Citation: Tounaoua MR, et al. (2025). Exploring The Role of Iron Accumulation and Muscle Parameters as Potential Risk Factors for Sarcopenia. Orthop Res J. 7(1):30.

Copyrights: Tounaoua MR, et al. © (2025).

ABSTRACT

Iron accumulation and sarcopenia represent a critical intersection in aging research, yet their relationship remains poorly understood. This study explores how iron biomarkers (ferritin, serum iron among others) and muscle parameters (BMI, SMI and so on) associate with sarcopenia risk in adults aged 60–80, while probing CRP’s paradoxical role. Our findings reveal ferritin’s marginal risk association, the protective effects of BMI/SMI, and CRP’s unexpected inverse relationship with sarcopenia, challenging conventional inflammation paradigms. These insights highlight the complexity of iron-muscle interactions in aging.

Keywords: Iron, Muscle Atrophy, Skeletal Muscle, Ferritin, Sarcopenia.