Eosinophilic Esophagitis is GERD against the Background of Allergies: Hypothesis. Diagnosis and Treatment

Dorot. Medical Center for Rehabilitation and Geriatrics, Netanya, Israel

*Corresponding Author: Michael D Levin, MD, Ph.D, Dorot. Medical Center for Rehabilitation and Geriatrics, Department of Pediatric Radiology of the 1-st State Hospital, Minsk, Belarus, Dorot. Medical Center for Rehabilitation and Geriatrics, Amnon veTamar, Netanya, Israel, Tel: 972-538281393, Email: [email protected]

Received Date: January 09, 2026

Published Date: January 28, 2026

Citation: Levin MD. (2026). Eosinophilic Esophagitis is GERD against the Background of Allergies: Hypothesis. Diagnosis and Treatment. Mathews J Gastroenterol Hepatol. 11(1):38.

Copyrights: Levin MD. © (2026).

ABSTRACT

Currently, it is considered that eosinophilic esophagitis (EoE) is an independent disease, which is often combined with gastroesophageal reflux disease (GERD). The clinical picture and histological findings are like GERD, but it should be distinguished from GERD, because these two conditions require different treatment. Based on the analysis of the literature and our own research, it was shown that (1) eosinophilic infiltration can affect other parts of the gastrointestinal tract. (2) PPI treatment is equally effective for both EoE and GERD. (3) Although the frequency of coincidence of EoE with GERD is not precisely determined, it is close to 100%. (4) The use of a lactose-free diet causes a clinical effect and a decrease in the number of eosinophils, both in EoE and GERD. (5) The radiographic picture of EoE indicates a dysfunction (shortening) of the lower esophageal sphincter (LES), which is characteristic of GERD. These facts suggest that EoE is an acid-dependent disorder like GERD, which differs from GERD in that it is an allergic reaction to inflammation caused by refluxate. The proposed diagnostics is based on reliable clinical symptoms (dysphagia, heartburn) combined with allergies, along with radiographic evidence of narrowing of the esophageal lumen and dysfunction of the LES. In the presence of the above symptoms, histological examination to determine the eosinophil count is not necessary, as recent data show that histology is not useful for differential diagnosis between GERD and EoE. Therefore, treatment for EoE involves treating both GERD and allergies. I propose a scientific discussion of the hypothesis of the pathophysiology of EoE and the advisability of modifying my proposed diagnostic and treatment methods for EoE.

Keywords: Eosinophilic Esophagitis, Gastroesophageal Reflux Disease, Allergy, Acid-Related Diseases, Lactose Intolerance, Pathophysiology, Diagnostics, Treatment.