Multi-System Biological Age Reversal Following MUSE Stem Cell Therapy: Case Reports

Eterna Health, Toronto, Ontario, Canada

*Corresponding Author: Adeel Khan, Eterna Health, Toronto, Ontario, Canada, Tel: +16472840024, Email: [email protected]

Received Date: July 22, 2025

Published Date: September 11, 2025

Citation: Khan A, et al. (2025). Multi-System Biological Age Reversal Following MUSE Stem Cell Therapy: Case Reports. Mathews J Case Rep. 10(4):210.

Copyrights: Khan A, et al. © (2025).

ABSTRACT

Background: Biological aging can be quantified using DNA methylation “epigenetic clocks,” which estimate an individual’s biological age based on methylation patterns. These clocks correlate strongly with chronological age and health risks, with Horvath’s seminal multi-tissue clock achieving a median error of ~3.6 years. However, traditional clocks may have limited resolution in individuals and do not pinpoint which organ systems are driving aging. Recent advances focus on biological noise – stochastic epigenetic dysregulation that increases with aging – and organ-specific epigenetic biomarkers to more precisely track aging and rejuvenation. Meanwhile, novel regenerative therapies such as multilineage differentiating stress- enduring (MUSE) stem cells have emerged. MUSE cells are endogenous non-tumorigenic pluripotent-like stem cells discovered in 2010 by Professor Mari Dezawa, capable of homing to damaged sites and orchestrating repair via differentiation and immunomodulation.

Keywords: MUSE Cells, Epigenetic Aging, DNA Methylation Clocks, Biological Age Reversal, Stem Cell Therapy, Regenerative Medicine.