¹Global Institute of Stem Cell Therapy and Research, Mexico-Playa del Carmen.

Avenida Paseo Tulum Local 01-04. Playacar Fase II, 77717, Playa del Carmen, Quintana Roo, Mexico

2Global Institute of Stem Cell Therapy and Research, Mexico

Calle 289 Alamo, Suite 5, Vicente Guerrero, 21970 Los Algodones, Baja California, USA

3 Global Institute of Stem Cell Therapy and Research,

4660 La Jolla Village Drive, Suite 100 & 200, San Diego, California 92122, USA

*Corresponding author: Dr. Anand Srivastava, Global Institute of Stem Cell Therapy and Research, Mexico-Playa del Carmen. Avenida Paseo Tulum Local 01-04. Playacar Fase II, 77717, Playa del Carmen, Quintana Roo & Global Institute of Stem Cell Therapy and Research, Mexico, Calle 289 Alamo, Suite 5, Vicente Guerrero, 21970 Los Algodones, Baja California & Global Institute of Stem Cell Therapy and Research, 4660 La Jolla Village Drive, Suite 100 & 200, San Diego, California 92122, USA; E-mail: [email protected].

Received Date: February 03, 2024

Published Date: March 07, 2024

Citation: Lopez S, et al. (2024). Mesenchymal Stem Cell Therapy in Cervical Spine Compression: A Case Report. Mathews J Case Rep. 9(3):156.

Copyrights: Lopez S, et al. © (2024).

ABSTRACT

The remarkable properties of Mesenchymal Stem Cells (MSC) have been recently investigated in a variety of clinical conditions with promising outcomes. Downregulation of the overproduction of proinflammatory cytokines through immunomodulation, along with the secretion of growth factors are perhaps the most investigated mechanisms of action of MSC. Recently, MSC therapy has received great attention while dealing with degenerative arthropathy-related ailments, including spinal cord-associated conditions, such as Cervical Spine Compression (CSC). Clinical diagnosis of CSC is often developed laterally with other pathologies, degeneration of tissue, and other related complications. Though surgery is often recommended in these sceneries, the invasiveness of this procedure is clear, and some patients are not candidates due to other diagnosed conditions. In this case report, a patient presenting a notorious case of CSC came to our clinic on August 2022 at Playa del Carmen, Mexico, to receive allogenic MSC therapy. Spinal stenosis at C5-C6 with mild cord compression was observable through Magnetic Resonance Imaging (MRI) during the first medical consultation. The medical protocol involved local infiltrations of adipose derived-MSC, MSC derived exosomes and Platelet Rich Plasma (PRP) within a 5-day period. Additionally, as part of a multidisciplinary approach, intravenous (IV) nutrition and O₂ therapy were performed. Three days after the MSC infiltration, improvement in joint pain and straighter standing was reported along with enhanced balance, supporting the anti-inflammatory properties of MSC. Five months after MSC therapy, a subsequent MRI showed noteworthy improvement in the spinal stenosis in C5-C6; along with a clinically significant decrease in muscle cramps and muscle spasms, which was attributable to the regenerative properties of MSC therapy. Overall, the patient’s quality of life improved and clinical evaluation stated spine surgery was no longer necessary.

Keywords: Cervical Spine, Disc Degenerative Disease, Immunomodulation, Inflammation, Mesenquimal Stem Cells.