Mathews Journal of Case Reports


Current Issue Volume 9, Issue 4 - 2024

Cytokine-Induced Neurogenesis for Bipolar Disorder: A Case Study

Takuji Shirasawa1,2*, Luis Carlos Aguilar Cobos3

1Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan

2Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan

3Livant Neurorecovery Center, Guadalajara, Mexico

*Corresponding author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, and Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan, Email: [email protected]

Received Date: March 22, 2024

Published Date: April 12, 2024

Citation: Shirasawa T, et al. (2024). Cytokine-Induced Neurogenesis for Bipolar Disorder: A Case Study. Mathews J Case Rep. 9(4):163.

Copyrights: Shirasawa T, et al. © (2024).


Bipolar disorder (BPD), formally called manic depression, is a mental health condition that causes extreme mood swings for which specific brain pathology has not yet been precisely defined. We administered cytokine-induced neurogenesis treatment to a 60-year-old male BPD patient to regenerate GABAergic neurons as well as glutamatergic neurons, which resulted in a successful regeneration of the atrophied hippocampus and disorganized cortical structures of the prefrontal cortex and anterior cingulate cortex, which was associated with improved emotional control and the resolution of electrophysiological abnormalities. To the best of our knowledge, this is the first case report demonstrating that cytokine-induced GABAergic and glutamatergic neurogenesis repairs brain pathology due to BPD and improves emotional control.

Keywords: Bipolar Disorder (BPD), Emotional Control, Cytokine, Neurogenesis, Prefrontal Cortex, Hippocampus, Anterior Cingulate Cortex.

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