Cytokine-Based Regenerative Treatment in Primary Sjögren Syndrome: A Case Report of the Improvement of Anti-SSA Antibodies, Salivary Gland Swelling, and Hippocampal Atrophy

¹Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan

²Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan

³Livant Neurorecovery Center, Guadalajara, Mexico

*Corresponding Author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan, and Shirasawa Anti-Aging Medical Institute, Tokyo 101-0062, Japan, E-mail: [email protected]

Received Date: July 02, 2026

Published Date: July 18, 2026

Citation: Shirasawa T, Cobos LCA. (2026). Cytokine-Based Regenerative Treatment in Primary Sjögren Syndrome: A Case Report of the Improvement of Anti-SSA Antibodies, Salivary Gland Swelling, and Hippocampal Atrophy. Mathews J Case Rep. 11(3):229.

Copyrights: Shirasawa T and Cobos LCA. © (2026).

ABSTRACT

Background: Primary Sjögren syndrome is a systemic autoimmune disease that can involve the glandular, pulmonary, cardiovascular, autonomic, and central nervous systems.

Case presentation: A 75-year-old woman with primary Sjögren syndrome presented with fatigue, dry mouth, and dizziness and had salivary gland swelling, anti-SSA/Ro antibody positivity, pulmonary fibrosis, cardiovascular involvement, autonomic dysfunction, and marked hippocampal atrophy. The patient received cytokine-based treatment combined with low-dose prednisolone. Longitudinal assessments included serological, imaging, neurophysiological, autonomic, and clinical evaluations.

Results: During the six-year follow-up period, anti-SSA/Ro antibody status became negative, salivary gland swelling decreased, dry mouth and fatigue improved, serum cortisol levels recovered, neurophysiological hyperexcitability appeared reduced, and hippocampal and entorhinal morphology showed apparent longitudinal changes on imaging. Cardiovascular findings remained largely stable, with a subsequent decrease in BNP after administration of an additional cytokine-based formulation, whereas pulmonary imaging showed progression despite preserved pulmonary function. These findings describe temporal associations and do not establish treatment causality.

Conclusion: This single case suggests a possible temporal association between cytokine-based treatment combined with low-dose prednisolone and improvement in selected serological, glandular, autonomic, and neurological findings in primary Sjögren syndrome. Because causality cannot be inferred from one case, further controlled studies are needed to evaluate the safety, reproducibility, and potential clinical relevance of this approach.

 Keywords: Primary Sjögren syndrome, Cytokine, Regenerative Medicine