Student Research Committee, Shiraz University of Medical Sciences, Shiraz ,Iran

*Corresponding author: Iman Dianat, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Email: [email protected]

Received Date: April 12, 2023

Publication Date: April 25, 2023

Citation: Zahraei SAH, et al. (2023). Alice in Wonderland Syndrome. Mathews J Case Rep. 8(6):110.

Copyright: Zahraei SAH, et al. © (2023)

ABSTRACT

In this paper, we investigate the so called “Alice in wonderland syndrome” (AIWS) disorder by first giving an introduction to this disorder and then providing more information on the history of this disease. In the next section, we look at the symptoms together with various examples with their similarities and exceptional signs as well as rare long-term studies which are very useful for physicians and can contribute to a better clinical diagnosis. Afterwards, the diseases that are associated with this syndrome are named and being aware of such diseases will not only provide new research topics for physicians, but also help them better treat and prevent them from giving other irrelevant treatment methods. Furthermore, besides the associated diseases other factors related to this syndrome is discussed. In addition, the existing diagnostic and treatment methods together with various examples are investigated. Finally, the results of some of the previously done studies are discussed based on their categories. In this article, we encounter some exceptional cases that according to their author are investigated for the first time, and this review provide accurate information which are useful for diagnosis and treatment as well as further research ideas.  

SEARCH STRATEGY

This disease is an extremely rare disease with few limited studies devoted to its investigation, such that less than 100 citations are retrieved in search engines like Pubmed using titles, abstracts and “Alice in wonderland” as the keyword. Even though these searches were done without typing the words “syndrome” or “disease”, many of the retrieved citations were either irrelevant papers or very simple case report studies.

RESULTS

We reach different conclusions in every section of this paper. For instance, in the introduction and history we conclude that this syndrome is in fact named after the novel with the same name. Discussing the symptoms we notice that this disorder can manifest itself without migraine headaches or even without previous illness or at any certain point. Discussing the diseases associated with this syndrome, we conclude that it can be associated with a wide range of disorders some of which have been reported for the first time in papers by different authors and further research may contribute in finding other new AIWS-associated disorders. In addition, the effectiveness of treatments, differences in diagnostic methods and the efficiency of nuclear medicine regarding diagnosis is further discussed in the conclusion.

Keywords: Rare disease, AIWS, Review, Alice in Wonderland syndrome