Mahdis Solhjoo1*,Alireza Rastgoo Haghi2,Nasim Golchin3,Negar Golchin4,Roham Shahbazi2
1Department of Medicine, Nassau University Medical Center, NY, USA.
2Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.
3Department of Medicine, Icahn School of Medicine at Mount Sinai Queens Hospital Center, NY, USA.
4Department of Oncology, Isfahan Milad Hospital, Isfahan, Iran.
Corresponding Author: Mahdis Solhjoo, Department of Medicine, Nassau University Medical Center, NY, USA, Tel: 15165720123; E-Mail: [email protected]
Received Date: 29 Aug 2018
Accepted Date: 05 Nov 2018
Published Date: 12 Nov 2018
Copyright © 2018 Solhjoo M
Citation: Solhjoo M, Haghi AR, Golchin N, Golchin N, et al. (2018). Expression of E-cadherin and Ki-67 in Gastric Cancer Patients and Correlation with Clinicopathological Factors. Mathews J Cancer Sci. 3(1): 015.
Introduction: Gastric carcinoma is the second leading cause of cancer-related death in the world. The aim of this study is to evaluate the role of E-cadherin and Ki-67 expression in gastric cancer and their correlation with clinicopathological factors.
Materials and methods: In this study, gastric cancer patients who underwent total gastrectomy were selected and their pathologic slides evaluated by immunohistochemical analysis to assess E-cadherin and Ki-67 level. Additional data including lymph node involvement, tumor site, and depth were also considered.
Results: Total of 52 patients were considered. The most common diagnosis was adenocarcinoma (82.7%). E-cadherin was negative in 46.7% of the patients while Ki-67 was present in 76.4% of the cases. There was a significant relation between E-cadherin and lymph nodes involvement (p=0.021). There was a significant relation between Ki-67 and the cancer grade (p=0.035) and patient gender (p=0.003). However, no other significant differences between the study parameters were noticed.
Conclusions: In this study, E-cadherin level was related to the number of involved lymph nodes, and Ki-67 level was related to the cancer grade and patient gender.
Gastric Cancer; Ki-67; E-cadherin