Mathews Journal of Psychiatry & Mental Health


Previous Issues Volume 6, Issue 1 - 2021

Genetic Variants associated with Persistent Depressive Disorder

Ramakrishnan V*, Lenika A

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE), Kelambakkam-603103, Tamilnadu, India

*Corresponding Author: Dr. Ramakrishnan V ,Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam - 603 103, Tamil Nadu, India, E-mail: [email protected]

Received Date: November 09, 2020

Published Date: February 05, 2021

Copyright: Ramakrishnan V, et al. © (2021).

Citation: Ramakrishnan V, et al. (2021). Genetic variants associated with Persistent Depressive Disorder. Mathews J Psychiatry Ment Health. (6)1:31.


Background and objectives: As with depression, persistent depressive disorder, recognized as dysthymia is one of the common psychiatric illnesses. According to the World Health Organization, over 350 million among the entire population, are affected by this condition. This study intends to cover and narrate the association of candidate genes with persistent depressive disorder.

Methods: A well-focused subject literature search should be chosen for this study from PubMed and PubMed Central literature review or narrative review is a type of review articles are used to focus on genetic variants are expected to have only minute effects on the whole disease risk, and numerous genetic factors amongst with environmental factors are possibly required for the progress and developing of major depressive disorder.

Results: Genetic association of a depressive disorder is vital for clinical-based studies, and also many researchers have suggested that common genetic variants, gene expression and pathways are related to depression. Thus, it is established those candidate genes are involved in the pathological process of depressive disorder such as CRY1, CRY2, MAOA, 5-HTT; BDNF, IL, and FKBP5 are mainly concerned with anxiety and depressive disorders.

Conclusion: To conclude, our findings in genetic literature confirms that association studies of candidate genes point to potential risk loci of persistent depressive disorder may play an important role in early stage identification and pathogenic risk assessment, thereby reducing the incidence among the PDD human community. Depression can be treated efficiently and easily but the main issue is to find out the associated risk factors and severity of the depression.

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