Mathews Journal of Pharmaceutical Science


Previous Issues Volume 4, Issue 1 - 2020

Synthesize and Antimicrobial Analysis of Schiff Base Ligand N-Salicylcefuroxime

Farhana Hoque, Tangina Akter Anni, Md. Shahidul Islam*

Department of Pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh

*Corresponding author: Md. Shahidul Islam, Assistant Professor, Department of Pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh, E-mail: [email protected]

Received Date: October 02, 2020

Published Date: October 29, 2020

Copyright: Islam MS, et al. ©2020.

Citation: Islam MS. (2020). Synthesize and antimicrobial analysis of Schiff base ligand N-salicylcefuroxime. Mathews J Pharm Sci. 4(1):03.


Schiff base ligand N-salicylcefuroxime was synthesized from cefuroxime and salicyldehyde to develop a more effective antibiotic. Bacterial infections have been a major health problem and the emergence of multi drug resistant complicates the situation. In the purpose of discovering more effective procurement, several antibiotics have been procured or synthesized. Advanced research of synthetic chemistry has pointed out several organic compounds with antimicrobial potentials, Schiff bases are one of such compounds. Cefuroxime is a bactericidal antibiotic. This research aimed to discuss the synthesis of a new schiff base from common antibiotic cefuroxime and salicyldehyde. This ligand synthesized and characterized by elemental analysis and some other physicochemical techniques. This synthesized compound was also characterized by different spectroscopic techniques. It was subjected to melting point determination, TLC (thin layer chromatography) determination, chemical tests, solubility test, etc. The schiff base was screened for in vitro anti-bacterial activity by disc diffusion method. The synthesized compound was found more anti-bacterial potential then cefuroxime.

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