Mathews Journal of Pharmaceutical Science


Previous Issues Volume 4, Issue 1 - 2020

Letter to the Editor Full-Text  PDF  

Over View Regarding Efficacy of Clostridium Botulinum Toxin (Botox) For the Management of Various Pathologies

Humaira Zafar1*, Irfan Ali Mirza2, Wajid Hussain3

1Professor of Pathology, Consultant Microbiologist, Al Nafees Medical College & Hospital, Islamabad

2Professor of Pathology & Head Department Of Microbiology, Consultant Microbiologist, Armed forces Institute of Pathology, Rawalpindi

3Assistant Professor of Pathology, Consultant Microbiologist, Department of Microbiology, Armed forces Institute of Pathology, Rawalpindi


*Corresponding author: Humaira Zafar, Prof. of Pathology, Consultant Microbiologist, Department of Pathology, Al Nafees Medical College & Hospital, Isra University Islamabad Campus, Pakistan, Tel: 0333-524-2761; E-mail:

Received Date: September 18, 2020

Published Date: October 23, 2020

Copyright: Zafar H, et al. ©2020.

Citation: Zafar H. (2020). Over View Regarding Efficacy of Clostridium Botulinum Toxin (Botox) for the Management of Various Pathologies. Mathews J Pharm Sci. 4(1):02.


The Botulinum toxin or Botox is virulent factor produced by Clostridium botulinum. It belongs to a group of Gram positive spore forming rods. Botulinum toxin is a neurotoxin which is inhibiting the release of acetylcholine at neuromuscular junction. The resultant effect is paralysis of specific group of muscles. This Botulinum toxin comprises of seven neurotoxins. Amongst all of them toxin type A and B harbors clinical significance especially in the field of medicine, surgery, and dermatology. The optimum dose ranges from 15 – 20 units. The effect starts within 24 hours to two weeks and last until 3 to 6 months. However published data was limited to assess its efficacy in various conditions. Therefore this review article was planned to get the insight regarding clinical efficacy and side effects of botox for various disorders. The results extracted from the review of literature showed that it is safe with minimum side effects to treat many medical and surgical conditions.

Conclusion: Usage of Botox is safe for the management of various medicines, surgery disorders. The good results can be seen even used for cosmetic purpose. Careful approach should be opted for immunosuppressed patients due to serious side effects.

KEYWORDS: Clostridium botulinum, Botox, Clinical efficacy, Cosmetic use, Use for Anal Fissure, Use for Ophthalmic conditions, Use for Depression, Side effects, Contraindications

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