Autosomal Recessive Syndromic Hinman Syndrome: A New Variant

Advisor Doctor and Expert Trainer, Baghdad Medical City and Iraqi Ministry of Health Baghdad, Iraq

*Corresponding Author: Aamir Jalal Al-Mosawi, Advisor Doctor and Expert Trainer, Baghdad Medical City and Iraqi Ministry of Health Baghdad, Iraq, Email: [email protected]

Received Date: December 22, 2025

Published Date: March 05, 2026

Citation: Al-Mosawi AJ. (2026). Autosomal Recessive Syndromic Hinman Syndrome: A New Variant. Mathews J Pediatr. 11(1):49.

Copyrights: Al-Mosawi AJ. © (2026).

ABSTRACT

Background: Nonneurogenic neurogenic bladder, or Hinman syndrome, is traditionally considered a functional voiding disorder in children without neurological or anatomical abnormalities. While often acquired, recent data suggest possible congenital or familial forms. Objective: To describe a unique familial cluster of Hinman syndrome in three sisters from Iraq, highlighting a likely autosomal recessive inheritance pattern and potential syndromic features. Patients and Methods: Three female siblings born to consanguineous parents presented with vesicoureteral reflux and symptoms consistent with Hinman syndrome. The eldest progressed to chronic renal insufficiency. All were treated with oral alfuzosin. Clinical assessment included evaluation of dysmorphic features and cognitive development. Parents and patient consents and the appropriate approval by the ethics committee have been ensured. Results: Alfuzosin therapy resulted in significant symptom improvement, with the eldest no longer requiring catheterization. The youngest sister exhibited multiple facial dysmorphic features alongside preserved cognitive function. The pattern of inheritance and clinical phenotype suggests a syndromic, autosomal recessive form of Hinman syndrome. Conclusion: This case series expands current understanding of Hinman-like disorders, indicating a possible genetic etiology. Early recognition and medical management with alpha-blockers may help preserve renal function and reduce complications.

Keywords: Hinman Syndrome, Neurogenic Bladder, Pharmacologic Management.