The Role of Mesenchymal Stem Cells in Modulating the Immune System and Repairing Lung Damage in ARDS Patients with SARS-COV-2

¹Marine Medicine Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
²Department of Basic Sciences, Faculty of Science, Imam Khamenei University, Zibakenar, Rasht, Iran
³Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
⁴Enzyme Technology Lab, Genetics & Metabolism Research Group, Pasteur Institute of Iran, Tehran, Iran
*Corresponding Author: Amir Nejad-Moghaddam, Marine Medicine Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Tel: +98-9112276563; E-mail: [email protected] 

Received Date: September 26, 2023

Publication Date: November 14, 2023

Citation: Nejad-Moghaddam A, et al. (2023). The Role of Mesenchymal Stem Cells in Modulating the Immune System and Repairing Lung Damage in ARDS Patients with SARS-COV-2. Mathews J Cytol Histol. 7(2):24.

DOI: https://doi.org/10.30654/MJCH.10024

Copyright: Nejad-Moghaddam A, et al. © (2023)

ABSTRACT
Disease characteristics and pathogenesis of coronavirus 2019 (COVID-19) have been greatly elucidated, but there is currently no specific treatment to induce regeneration of lung damage. In severe cases, acute SARS-CoV-2 infection leads to a deficiency of the immune system and consequently damage to immune responses, resulting in impaired immune cell function. Mesenchymal stem cells (MSCs), which are involved in the regulation and regeneration of the immune system, can be considered as a treatment option because they may regulate the inflammatory response caused by cytokine storms and improve lung damage. Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. Since the outbreak of COVID-19, a series of MSC-related clinical trials have been performed. The findings show that MSC treatment not only reduces lung damage but also improves immune function by reducing cytokine storms. In this article, we reviewed therapeutic advances and trials of using MSCs to treat SARS-CoV-2 injury.
Keywords: Cytokine Storm, Cell Therapy, Mesenchymal Stem Cells, Inflammatory Response, Regeneration, Coronavirus 2019 (COVID-19), SARS-CoV-2, ARDS