Mathews Journal of Cytology and Histology


Previous Issues Volume 1, Issue 1 - 2017

Review Article Full-Text  PDF  

The Cytomorphological Spectrum of Papillary Lesions in the Breast

Torill Sauer1 *

Department of Pathology, Akershus University Hospital and University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Campus Ahus 1478 Lørenskog, Norway.
Corresponding Author: Torill Sauer, Department of Pathology, Akershus University Hospital, 1478 Lørenskog, Norway, 
Tel: +4767964599, E-Mail: [email protected]

Received Date: 20 Sep 2017  
Accepted Date: 09 Oct 2017  
Published Date: 13 Oct 2017

Copyright © 2017 Sauer T

Citation: Sauer T. (2017). The Cytomorphological Spectrum of Papillary Lesions in the Breast.Mathews J Cytol Histol. 1(1): 005.


The objective of this review is to illustrate the broad spectrum of papillary lesions that can be found in breast fine needle aspirations (FNAC).
Papillary tumors of the breast comprise lesions of variable morphology and include entities ranging from benign to high grade malignant. Features of papillary neoplasms invariably describe branching three-dimensional papillary clusters with delicate fibrovascular cords. Cytomorphological criteria for benign and low-grade malignant entities overlap and a definite cytological diagnosis is not always possible. Cellular papillomas may harbor areas of ductal carcinoma in situ (DCIS), atypical ductal hyperplasia (ADH) or lobular neoplasia. DCIS can be both high grade and non-high grade. Immunocytochemistry (ICC) can be helpful, providing there is adequate material for ICC. Relatively high error rates, false negatives as well as false positive diagnoses can be found. In general, papillary lesions may be recognized as such. Reporting strategies will often recommend caution if trying to differentiate benign, cellular papillomas from low-grade carcinomas.
In conclusion, papillary lesions present with a broad spectrum of cytomorphological features that are illustrated in this review


Breast Cytopathology; Cytomorphology; Fine Needle Aspiration; FNB – Proliferative Lesions; Morphology; Papillary Carcinoma.

Creative Commons License

© 2015 Mathews Open Access Journals. All Rights Reserved.

Open Access by Mathews Open Access Journals is licensed under a
Creative Commons Attribution 4.0 International License.
Based On a Work at