Corresponding Author: Anubha Bajaj, Consultant Histopathologist, A.B. Diagnostics, Delhi, India, E-mail: [email protected]
Received Date: September 11, 2020
Published Date: October 12, 2020
Copyright ©: Anubha B. ©2020.
Citation: Anubha B. (2020). Metarteriole and Mesenchyme - Cellular Angiofibroma. Mathews J Cytol Histol. 4(1): 15.
Cellular angiofibroma is a contemporary, benign, mesenchymal neoplasm comprised of dual cellular components of spindle-shaped cells and prominent, stromal blood vessels. The neoplasm is commonly delineated in middle aged adults of 40 years to 60 years and typically incriminates subcutaneous tissue of vulvovaginal region in females and inguinoscrotal region in males. An asymptomatic, painless or painful, firm, gradually progressive soft tissue mass is usually discerned. Minimally to moderately cellular neoplasm displays an abundant myxoid stroma intermixed with tumour cells fascicles. Characteristically, bundles of bland spindle- shaped cells encompassing well developed vascular articulations and an intervening collagenous or myxoidstroma with numerous, miniature to medium sized blood vessels with perivascular hyaline fibrosis is exemplified. Tumour cells are immune reactive to vimentin, CD34, CD99, CD31, smooth muscle actin (SMA), oestrogen receptors (ER), progesterone receptors (PR) and are immune non reactive to S100 protein, desmin, epithelial membrane antigen (EMA), caldesmon and cytokeratin. The neoplasm can be subjected to surgical resection.
KEYWORDS: Mesenchymal; Fibroblastic; Vascular; Stromal