Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Corresponding author: Lili Chen, Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA, E-mail: [email protected]
Received Date: March 16, 2021
Published Date: May 21, 2021
Copyright: Chen L © (2021).
Citation: Chen L. (2021). Clinical Applications of Pulsed LowDose-Rate Radiation Therapy. Mathews J Cancer Sci. 6(1):27.
Pulsed low dose-rate radiotherapy (PLDR) is a novel radiotherapy technique for cancer treatments, which relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. PLDR delivers the daily radiation dose in a number of sub-fractions (pulses) with a preset time interval to achieve an effective low dose rate. PLDR can be delivered on existing clinical machines using different treatment optimization strategies and delivery techniques. Clinical trials have been carried out to study the application of PLDR for various cancers especially for recurrent cancers. Preliminary results from these clinical studies have shown favorable outcome. This paper briefly describes the PLDR technique, the planning requirements and its clinical applications in cancer treatment.
KEYWORDS: External beam radiotherapy (EBRT); Dose rate effect; Hyper-radiosensitivity; Tumor control; Normal tissue toxicity; Pulsed low dose-rate radiotherapy (PLDR); Transition dose