C-reactive Protein in the Assessment of Acute Pancreatitis Severity

¹University Department of General Surgery, Ain Taya Hospital, Algeria

²General Surgery, Department of the Hospital of Thénia, Algeria & University of Health Sciences, Mujahid Doctor Youcef Al-Khatib, Algeria

*Corresponding author: Reda Khiali, University Department of General Surgery, Ain Taya Hospital, Algeria & University of Health Sciences, Mujahid Doctor Youcef Al-Khatib, Algeria, Phone: 00213555265010, Email: [email protected]

Received Date: March 28, 2026

Published Date: April 16, 2026

Citation: Khiali R, et al. (2026). C-reactive Protein in the Assessment of Acute Pancreatitis Severity. Mathews J Surg. 9(1):43.

Copyrights: Khiali R, et al. © (2026).

ABSTRACT

Introduction: Acute pancreatitis is a common inflammatory disease of the pancreas, with several etiologies and an unpredictable course. The early identification of severe forms remains a major challenge in care; it is precisely the degree of severity that conditions its overall and etiological management. C-reactive protein (CRP), a biological marker of inflammation, is widely used in this context, alongside several other clinical, biological, radiological parameters, but also combines multiparametric scores. Objective: To assess the role of CRP in the assessment of the occurrence of severe forms of acute pancreatitis. Methods: Retrospective observational and analytical study of patients hospitalized for the management of acute pancreatitis. CRP levels were measured serially and correlated with severity defined according to the revised Atlanta Classification 2025. CRP was routinely measured at the 48th hour of the relapse, quantified, and depending on the result, patients were assigned to three groups: Group 1: CRP from 0 to 100mg, Group 2: CRP between 100 and 150 mg, Group 3: CRP greater than or equal to 150 mg. Results: A significant increase in CRP, particularly ≥ 150 mg/L at 48 hours, was associated with severe forms and the presence of local and systemic complications. Conclusion: CRP is a simple and accessible tool for assessing the severity of acute pancreatitis, provided that it is integrated into a multimodal approach.

Keywords: Acute Pancreatitis, C-reactive Protein, Gravity, Inflammation, Prognosis.