Mathews Journal of Pharmaceutical Science


Current Issue Volume 8, Issue 1 - 2024

Synthesis and Antidiseas Evaluation of Some Bis-Heteroaryls (Thiophene or Selenophene) 1,2,3-triazoles C-trimethylsilylated

Paolo Zanirato1,*, Silvia Businelli2

1Academy of Sciences of Bologna, via Zamboni 31, Bologna, Italy

2Fondatrice Mirasolvia, Italy

*Corresponding author: Dr. Paolo Zanirato, Academy of Sciences of Bologna, via Zamboni 31, Bologna, Italy, E-mail: [email protected]

Received Date: June 07, 2024

Published Date: June 28, 2024

Citation: Zanirato P, et al. (2024). Synthesis and Antidiseas Evaluation of Some Bis-Heteroaryls (Thiophene or Selenophene) 1,2,3-triazoles C-trimethylsilylated. Mathews J Pharma Sci. 8(1):29.

Copyrights: Zanirato P, et al © (2024).


This experimental work is part of a research project that includes both the aspect relating to the synthesis, by the 1,3-dipolar cycloadditions (1,3-DC), of a series of new compounds, 1-heteroaryl-1,2,3-triazoles C-4 (or C-5) silylates, and the study of their potential biological applications [1].

The eleven triazole compounds, obtained by reaction of a heteroaryl azide (1a-11a) and trimethylsily acetylene (TMSiAc), directly provides the corresponding heteroaryl triazole ring, at room or low temperature, by 1,3-DC occurring regioselectively with high yelds [2-4].

The discussion is therefore into three parts; in the first part the topic relating to the synthetic procedure for each of the compounds (1-11) is specified. Consequently, this part includes the study regarding the electronic structure of the heteroaryl azido group and the 1,3-dipolar cycloadditions (1,3-DC’s) reaction leading to the final triazole adduct [5-8].

The second part deals with the characterization and structural study of the synthesized (azides and triazoles) products through IR, 1H- and 13C-NMR and mass spectroscopic analysis (MS).

The third part is aimed at determining the potential pharmacological activity of the newly synthesized triazoles. The products were analyzed using appropriate test, from the experimental protocol validated by specialized American research institutes such as the Tuberculosis Antimicrobial Acquisition Facility (TAACF) and the National Cancer Institute (NCI) [9,10].

Keywords: Heteroaryl Azides, 1,3-dipolar Cycloadditions, Heteroaryl Triazoles, C4-triazoles Silylated, Spectroscopic Analysis, Tubercolosis, Cancer.

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