Mathews Journal of Pharmaceutical Science


Previous Issues Volume 1, Issue 1 - 2016

Research Article Full-Text  PDF  

Naturally Occurring Isocyano/Isothiocyanato Compounds: Their Pharmacological and SAR Activities

Dmitri O Levitsky1 , Tatyana A Gloriozova2 , Vladimir V Poroikov2 , Valery M Dembitsky3

1CNRS UMR 6204, Biotechnologie, Biocatalyse et Bioregulation, Faculty des Sciences et des Techniques, University de Nantes Nantes, 44322 Nantes Cedex 03, France.
2Institute of Biomedical Chemistry, Moscow 119121, Russia.
3Institute for Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel.
Corresponding Author:Valery M. Dembitsky, Institute for Drug Discovery, 8 Ha-Marpe Str, P.O. Box 45289, Jerusalem 91451, Israel, Tel: +972-526877444; E-Mail: [email protected]
Received Date: 27 Feb 2016   
Accepted Date: 08 Mar 2016   
Published Date: 18 Mar 2016
Copyright © 2016 Dembitsky VM
Citation: Levitsky DO, Gloriozova TA, Poroikov VV and Dembitsky VM. (2016). Naturally Occurring Isocyano/ Isothiocyanato Compounds: Their Pharmacological and SAR Activities. Mathews J Pharm Sci. 1(1): 003


Rapid and accurate identification of microorganisms is an essential part of pharmaceutical analysis. Contaminants found in ingredients, water for pharmaceutical use, the manufacturing environment, intermediates, and finished products are identified to assist in product investigations. There are number of phenotypic, genotypic and proteotypic methods. A comparison of the database size of representative methods, as well as accuracy of these systems is presented in the review. Emphasis is given to the features of methods and factors affecting the result of identification. Some species of microorganisms within one genus, which determination is problematic from both a genotypic and a phenotypic perspective, are discussed in details. Validation of identification methods is the most important and challenging part of proper automated system choice. Approaches to the evaluation of the system are highlighted in the review.


The MIC (minimum inhibitory concentration) is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. Pa and Pi value tells the probability of activity. Pa means probability to be active and Pi means probability to be inactive. The IC50 is a measure of how effective a drug is. It indicates how much of a particular drug or other substance is needed to inhibit a given biological process (or component of a process, i.e. an enzyme, cell, cell receptor or microorganism) by half.

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