Formulation and Evaluation of Fluvastatin Sodium Modified Pulsincap Delivery System

Pulla Reddy Institute of Pharmacy, Hyderabad, India

*Corresponding author: Dr. K Ravi Kumar, Pulla Reddy Institute of Pharmacy, Department of Pharmaceutics, Domadugu, Gummadidala (M), Sangareddy District, Telangana State, India, Email: [email protected]

Received Date: January 02, 2025

Published Date: May 13, 2025

Citation: Ravi Kumar K, et al. (2025). Formulation and Evaluation of Fluvastatin Sodium Modified Pulsincap Delivery System. Mathews J Pharma Sci. 9(2):49.

Copyrights: Ravi Kumar K, et al. © (2025).

ABSTRACT

The study focuses on the formulation and evaluation of a floating pulsatile drug delivery system for Fluvastatin Sodium, aimed at achieving site- and time-specific drug release in alignment with circadian rhythms. Fluvastatin Sodium, a short half-life statin, is used to reduce plasma cholesterol levels and prevent cardiovascular diseases. The innovative system is designed to release the drug after a predetermined lag time, targeting early morning hours when cholesterol synthesis peaks. This chronotherapeutic approach improves bioavailability, therapeutic efficacy, and patient compliance. The methodology involved the preparation of immediate-release core tablets, pulsatile tablets, and floating pulsatile formulations using polymers like HPMC. Evaluation tests included pre-compression parameters, in-vitro dissolution, buoyancy studies, and stability assessments. Results demonstrated successful lag-phase control and subsequent burst drug release, confirming the system’s suitability for nocturnal hypercholesterolemia. Stability studies further validated the robustness of the formulation. The developed system ensures improved therapeutic outcomes, offering a promising solution for chronotherapy in hypercholesterolemia management.

Keywords: Fluvastatin Sodium, Pulsatile Drug Delivery System, Chronotherapy, Floating Drug Delivery, Circadian Rhythm, Bioavailability.