Naresh Kshirasagar1*, Srilatha Malvey2, Gudikandula Harika3, Mallam Ranadheer Kumar1
1Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Telangana, India
2Vikas college of Pharmacy, Jangaon, Telangana, India
3Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, Telangana, India
*Corresponding Author: Naresh Kshirasagar, Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Telangana, India; Tel: 9676354445; Email: [email protected]
Received Date: 17 February 2023
Published Date: 04 April 2023
Citation: Kshirasagar N, et al. (2023). Formulation and Evaluation of Flurbiprofen Loaded Microsponges in Capsule for Sustained Drug Delivery. Mathews J Pharma Sci. 7(2):16.
Copyrights: Kshirasagar N, et al. © (2023).
The new investigation in this present work is to develop microsponges constructed novel drug delivery system for sustained action of Flurbiprofen. Various techniques are involved, among them, Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose with different drug: polymer ratio for development of microsponges, for optimization purposes, several factors are considered in investigation. Several evaluation studies for the formed microsponges were carried out FT-IR, SEM, particle size analysis, morphology, encapsulation efficiency and in vitro drug release studies were carried out. Finally, it was concluded that there is no drug polymer interaction as per FT-IR. Encapsulation efficiency, particle size and drug content showed higher impact on alteration of drug polymer ratio. SEM studies showed that morphological microsponges are spherical and porous in nature and with mean particle size of 30.11 ± 0.14 μm. The capsule loaded with microsponges, were followed by In vitro drug release studies and found to release the drug for sustained manner that is 98.12 ±0.63 % of release upto 12 hrs.
Keywords: Microsponges, Flurbiprofen, Capsule, Sustained action