Antitumor Acetylenic Lipids

¹National Institute of Water and Atmospheric Research, Private Bag 14-901, Wellington 6241, New Zealand.
²Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
³Institute for Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel.
Corresponding Author:Valery M. Dembitsky, Institute for Drug Discovery, 8 Ha-Marpe Str, P.O. Box 45289, Jerusalem 91451, Israel, Tel: +972-526877444; E-Mail: [email protected]
Received Date: 14 Mar 2016  
Accepted Date: 21 Mar 2016  
Published Date: 23 Mar 2016
Copyright © 2016 Dembitsky VM
Citation: Kilimnik A, Kuklev DV and Dembitsky VM. (2016). Antitumor Acetylenic Lipids. Mathews J Pharm Sci. 1(1): 005.

ABSTRACT:

This article describes antitumor acetylenic lipids and related compounds obtained from living organisms. Acetylenic lipids belong to a class of molecules containing triple bond(s). They are found in algae, plants, fungi, microorganisms, and marine invertebrates. Although polyacetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 50 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, anti-fungal, HIV inhibitory and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medical, pharmacological, medicinal chemistry, and/or pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 90 acetylenic lipids, including fatty acids, glycerides, sterols and carotenoids isolated from living organisms.

KEYWORDS:

Acetylenic; Polyacetylenes, Antitumor; Sterols; Carotenoids; Fatty Acids; Lipids.