Mathews Journal of Pharmaceutical Science

2474-753X

Current Issue Volume 8, Issue 1 - 2024

A Review on Analytical Methodologies for the Estimation of Anti-Retroviral Drugs Cabotegravir and Rilpivirine

Vaibhav Adhao*, Jaya Ambhore, Anant Bhuskat, Dishali Talokar

Department of Quality Assurance, Dr. Rajendra Gode College of Pharmacy, Maharashtra, India

*Corresponding author: Vaibhav Adhao, Department of Quality Assurance, Dr. Rajendra Gode College of Pharmacy, Malkapur, Dist. Buldana, Maharashtra, India, Pin-443101, E-mail: [email protected]

Received Date: June 07, 2024

Published Date: July 02, 2024

Citation: Adhao V, et al. (2024). A Review on Analytical Methodologies for the Estimation of Anti-Retroviral Drugs Cabotegravir and Rilpivirine. Mathews J Pharma Sci. 8(1):30.

Copyrights: Adhao V, et al. © (2024).

ABSTRACT

Acquired Immune Deficiency syndrome (AIDS) is infections resulting from the damage to the human immune system. A significant shift in the prognosis of individuals living with HIV has occurred due to the widespread use of highly active antiretroviral treatments. Unfortunately, the lifelong side effects of such treatments raise concerns about maintaining therapeutic efficacy as well as long-term tolerability.

The FDA recently approved the combination of the most promising leading molecules, Cabotegravir and Rilpivirine, in 2021. The objective of this manuscript is to critically analyze the existing literature concerning a range of chromatography techniques that can be used concurrently and separately to ascertain the presence of antiretroviral medications in both biological samples and pharmaceutical preparations. These two drugs Cabotegravir and rilpivirine were selected because of their extensive use as anti-viral drug in combination.

The development and validation of such therapeutic agents are challenging work for the analysts. Therefore, the proposed review integrally addresses the analytical reports of Cabotegravir and Rilpivirine recorded in the literature databases like Scopus, Web of Science, Google Scholar, Pub-Med, and through many other sources. It has been remarked that for the development of many analytical techniques were used for addressing the qualitative and quantitative estimation of Cabotegravir and Rilpivirine from various pharmaceutical and biological matrices. The hyphenated and chromatographic techniques are frequently used for analysis of cited drug. The review provides an overview of different chromatographic techniques, such as HPLC, RP-HPLC, UPLC and HPTLC. This will facilitate the analytical chemist to make use of the method for the routine analysis for the antiviral drug Cabotegravir and Rilpivirine. It will also focus on several available chromatographic conditions with different instruments used. So it will reduce time for the analytical chemist required for the analytical method development and also helps in formulation development.

Keywords: AIDS, HIV, Cabotegravir, Rilpivirine, Method, Development, Validation.


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