Sensorineural Hearing Loss: Overview and E3 Ligase Inhibition for Transcription Factor ATOH1 Survival

Medical Imaging, Lake Erie College of Osteopathic Medicine, Bradenton, USA

*Corresponding author: Mr. Waseem Syed, Medical Imaging, Lake Erie College of Osteopathic Medicine, Bradenton, 7507 Park Village Dr Jacksonville FL, 32256, USA, Tel: 4088056950; Email: [email protected]

Received Date: June 26, 2025

Published Date: July 23, 2025

Citation: Syed W. (2025). Sensorineural Hearing Loss: Overview and E3 Ligase Inhibition for Transcription Factor ATOH1 Survival. Mathews J Otolaryngol. 4(1):10.

Copyrights: : Syed W. © (2025).

ABSTRACT

This article is an examination of sensorineural hearing loss with potential reversal of symptoms through molecular modifications. Sensorineural hearing loss is a condition that plagues many patients, primarily the elderly, and can significantly lower the quality of life in these individuals. Although cochlear hair cells are incapable of regenerating, transcription factor atonal bHLH transcription factor 1 (ATOH1) is of interest as it is known to induce embryological differentiation of stem cells into hair cells. This article seeks to establish the basis of this transcription factor as a pharmacological target to aid those suffering from sensorineural hearing loss. Using data and information collected from previously published articles, manipulation of an organism’s natural protein recycling matrix, proteosome-ubiquitin system, via the use of E3 ligases may allow for prevention of the degradation of ATOH1 transcription factors. The compound is shown to have cysteine bases, which can be targeted utilizing electrophilic compounds. Results, however, have yet to be implemented in a laboratory environment but yield a promising opportunity for further evaluation of treating sensorineural hearing loss.

Keywords: Sensorineural Hearing Loss, Otolaryngology, ATOH1, Proteosome, E3 Ligases, Cystine Residues, Hearing Loss, Cochlea.