Intracranial Metastasis of Oral Squamous Cell Carcinoma: A Case Report

¹Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA

²Otolaryngologist, Novi, MI, USA

*Corresponding author: Mr. Waseem Syed, BS, Medical Student, Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA, Tel: 4088056950; Emails: [email protected]; [email protected]

Received Date: January 04, 2026

Published Date: February 04, 2026

Citation: Syed W, et al. (2026). Intracranial Metastasis of Oral Squamous Cell Carcinoma: A Case Report. Mathews J Otolaryngol. 5(1):13.

Copyrights: Syed W, et al. © (2026).

ABSTRACT

Brain metastasis from oral squamous cell carcinoma is exceptionally rare with only a few instances mentioned in the literature. Malignancies of the head and neck have a link to tobacco and alcohol usage. Head and neck cancer Oral squamous cell carcinoma (OSCC) is a malignancy of the head and neck region most strongly linked to tobacco and alcohol use, which account for up to 80% of cases. Standard treatments such as surgery, chemotherapy, and radiotherapy are often accompanied by adverse effects including oral mucositis, dysgeusia, xerostomia, and pain, which can precipitate dehydration, electrolyte imbalance, and malnutrition. While distant metastases from OSCC are uncommon, they most frequently involve the lungs, liver, and bones; brain metastases are extremely rare. Human papillomavirus (HPV)-associated OSCC represents a biologically distinct subtype with differing carcinogenesis, risk factors, and prognosis compared to HPV-negative disease. This report describes an exceptionally rare case of HPV-associated OSCC with brain metastasis, highlighting the complex multidisciplinary management required.

Keywords: Oral Squamous Cell Carcinoma, HPV, Oropharyngeal Cancer.