Internal Medicine Department, Faculty of Medicine, Ainshams University, Cairo, Egypt
Corresponding author: Sarah El-Nakeep, MD, Internal Medicine Department, Faculty of Medicine, Ainshams University, Cairo, Egypt, E-mail: [email protected]
Received Date: January 20, 2021
Published Date: February 16, 2021
Citation: Sarah El-Nakeep. (2021). Literature Review of the Published Human Clinical Trials: On COVID-19 Vaccines. Mathews J Immunol Allergy. (5)1:11.
Copyright: Sarah El-Nakeep. © 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: With the release of two vaccines after FDA approval, we are entering phase IV or as it is called Post-marketing phase. This phase is responsible for the mass vaccination and the herd immunity we need to end the pandemic.
Methods: the author searched PubMed for the keywords “Vaccine, COVID-19, and SARS-CoV2”, along with following the announcements of the various scientific communities.
Results: No phase IV trial data has been published till the time being, but only published data of Phases I-II and III were found by the literature search. The author discussed the limitations of the studies and the promised outcomes measured in those studies.
Conclusions: Waiting for phase IV data yet to be published; the author has examined the benefits and limitations of each vaccine.