Mathews Journal of HIV/AIDS

2474-6916

Previous Issues Volume 9, Issue 1 - 2026

Co-infection of HIV and Hepatitis C in Iran

SeyedAhmad SeyedAlinaghi1,2, Pegah Mirzapour1,*

1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

2Research Development Center, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding author: Pegah Mirzapour, Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran, Email: [email protected]

Received Date: May 12, 2026

Published Date: June 09, 2026

Citation: SeyedAlinaghi S, et al. (2026). Co-infection of HIV and Hepatitis C in Iran. Mathews J HIV AIDS. 9(1):27.

Copyrights: SeyedAlinaghi S, et al. © (2026).

LETTER TO EDITOR

Dear Editor,

The common co-infections with HIV are viral hepatitis including Hepatitis B and C. During approximately 1990–2000 decades, due to the predominant route of HIV transmission being injection drug use (IDU), Hepatitis C was particularly common among men living with HIV (MLWH), reaching as high as 80-90% in some studies [1-5].

Among women living with HIV (WLWH), the common transmission route was unprotected sexual contact, while sexual transmission of hepatitis C was very rare. Therefore, hepatitis C co-infection with HIV is much lower among WLWH compared to MLWH. Currently, due to a shift in the HIV transmission pattern from IDU to unprotected sexual contact, hepatitis C co-infection with HIV has significantly decreased, reaching about 20-30% in various studies [1,2,4,6]. In addition to IDU, the transmission of Hepatitis C in Iran is greatly influenced by tattooing, especially tattooing in prisons, which may be because of unhygienic condition [7-10]. Therefore, this decline in hepatitis C infection among people with HIV, besides indicating the shift in transmission pattern from IDU to unprotected sexual contact, highlights the need to pay attention to the implementation of prevention programs for transmission thorough sexual relationship.

IDU alone has become a social stigma in Iran, to the extent that people who use drugs are reluctant to do so because of the stigma, which has led to a decrease in IDU in the society. Furthermore, harm reduction programs, the most important of which is the methadone maintenance treatment (MMT) program that has been implemented in Iran since 2000, have also reduced IDU. The distribution of disposable syringes and needles has also helped preventing the HIV and hepatitis C transmission, which is currently being done in Drop-in Centers (DICs). In conclusion, the continued robust implementation of harm reduction programs, especially MMT, is recommended to reduce the incidence of hepatitis C in Iran.

REFERENCES

  1. SeyedAlinaghi S, Jam S, Mehrkhani F, Fattahi F, Sabzvari D, Kourorian Z, et al. (2011). Hepatitis-C and hepatitis-B co-infections in patients with human immunodeficiency virus in Tehran, Iran. Acta Med Iran. 49(4):252-257.
  2. Badie BM, SeyedAlinaghi S, Chaman R, Hosseini M, Hasibi M, Moharrami B, et al. (2022). Frequency and Correlates of Co-Infection Hepatitis C and Hepatitis B with HIV. (2011). Knowledge and Health in Basic Medical Sciences. 6(3):40-43.
  3. Hosseini M, Seyedalinaghi S, Kheirandish P, Esmaeili JG, Shirzad H, Karami N, et al. (2010). Prevalence and correlates of co-infection with human immunodeficiency virus and hepatitis C virus in male injection drug users in Iran. Archives of Iranian Medicine. 13(4):318.
  4. SeyedAlinaghi S, Valiollahi P, Paydary K, Emamzadeh-Fard S, Mohraz M. (2012). Prevalence of hepatitis B (HBV) and C (HCV) viruses coinfections among HIV infected people in Iran. J AIDS & HIV Res. 4:181-186.
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  6. SeyedAlinaghi S, Taj L, Mazaheri-Tehrani E, Ahsani-Nasab S, Abedinzadeh N, McFarland W, et al. (2021). HIV in Iran: onset, responses, and future directions. AIDS. 35(4):529-542.
  7. Kheirandish P, SeyedAlinaghi S, Jahani M, Shirzad H, Seyed Ahmadian M, Majidi A, et al. (2009). Prevalence and correlates of hepatitis C infection among male injection drug users in detention, Tehran, Iran. J Urban Health. 86(6):902-928.
  8. SeyedAlinaghi S, Farhoudi B, Shahmohamadi E, Rasoolinejad M, Hasannezhad M, Rashidi MR, et al. (2023). Prevalence of and risk factors for HCV among incarcerated people at Great Tehran Prison: a cross-sectional study. Int J Prison Health. 19(4):536-544.
  9. Pashangzadeh S, SeyedAlinaghi S, Dadras O, Pashaei Z, Soleymanzadeh M, Barzegary A, et al. (2022). Prevalence of Hepatitis in Prisoners: A Systematic Review of Current Evidence. Infect Disord Drug Targets. 22(8):61-72.
  10. SeyedAlinaghi S, Mahmoodi T, Farhoudi B, Abiri A, Boosiraz A, Mirzapour P, et al. (2026). Prevalence and risk factors of Hepatitis C virus infection among garbage collectors in Tehran, Iran. JIMC. In Press.

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