Superparamagnetic Nanoparticles as Game-Changers for Advanced Dentistry

¹MSc in International Health Management, Berlin School of Business and Innovation, Berlin, Germany

²Department of Oral Maxillofacial Surgery, Dow University of Health Science, Karachi, Pakistan

³Department of Chemistry, Faculty of Science, University of Agriculture, Faisalabad, Pakistan

⁴School of Architecture, Computing and Engineering, University of East London, Docklands Campus, University Way, London, UK

*Corresponding author: Noor Zulfiqar, Department of Chemistry, Faculty of Science, University of Agriculture, Faisalabad, Pakistan, Phone: +923178354635, E-mails: [email protected]; [email protected]

Received Date: December 23, 2025

Published Date: January 30, 2025

Citation: Asif MU, Zulfiqar N, et al. (2026). Superparamagnetic Nanoparticles as Game-Changers for Advanced Dentistry. Mathews J Dentistry. 10(1):61.

Copyrights: Asif MU, et al. © (2026).

ABSTRACT

Magnetite nanoparticles (Fe₃O₄ NPs) have emerged as multifunctional nanomaterials with significant potential in modern dentistry due to their unique magnetic properties, biocompatibility, and ease of surface functionalization. Recent advances in nanotechnology have enabled their application in antimicrobial therapy, drug delivery, dental implants, regenerative dentistry, diagnostic imaging, and orthodontics. This review critically summarizes the synthesis strategies, physicochemical properties, and biological interactions of magnetite nanoparticles, with a particular focus on their current and prospective applications in dentistry. The mechanisms underlying their antibacterial, biofilm-disruptive, and regenerative effects are discussed, along with safety, toxicity, and clinical translation challenges. Finally, future research directions and opportunities for integrating Fe₃O₄ nanoparticles into next-generation dental materials and therapies are highlighted.

Keywords: Magnetite Nanoparticles, Fe₃O₄, Dentistry, Antimicrobial Activity, Drug Delivery, Dental implants, Regenerative Dentistry, Nanotechnology.