Immediate Hypersensitivity Reaction During Facial Collagen Mesotherapy in a Patient with Previous Tolerance: A Case Report

¹Family Medicine Department, Trabzon University Medicine Faculty, Trabzon, Turkey

²Emergency Medicine, Kolon Hospital, Şişli, İstanbul, Turkey

*Corresponding author: Yilmaz Sezgin, MD. Family Medicine Clinic, Medicine Faculty, Trabzon Üniversity, Turkey & Kanuni Training and Research Hospital, Kaşüstü Neighbourhood, Yomra, Trabzon, Turkey, Tel: +905383425644, E-mail: [email protected]

Received Date: March 27, 2026

Published Date: April 16, 2026

Citation: Sezgin Y, et al. (2026). Immediate Hypersensitivity Reaction During Facial Collagen Mesotherapy in a Patient with Previous Tolerance: A Case Report. Mathews J Emergency Med. 10(1):70.

Copyrights: Sezgin Y, et al. © (2026).

ABSTRACT

Mesotherapy is widely used in aesthetic dermatology for skin rejuvenation. Although collagen-based formulations are generally considered safe, unexpected adverse reactions may occur. We report a case of an acute hypersensitivity reaction that developed during full-face collagen mesotherapy in a patient who had previously tolerated the same treatment without complications. Within minutes after the injections began, the patient developed sudden diffuse facial erythema. The procedure was immediately discontinued, and intravenous antihistamine therapy was administered, resulting in rapid clinical improvement. No systemic symptoms or delayed reactions were observed during follow-up. This case highlights that hypersensitivity reactions may arise unexpectedly even in previously tolerant individuals and emphasizes the importance of early recognition and prompt management during aesthetic procedures.

Keywords: Mesotherapy, Hypersensitivity, Facial Collagen.