Mathews Journal of Anesthesia


Previous Issues Volume 2, Issue 1 - 2018

Research Article Full-Text  PDF  

Postoperative Scheduled Intravenous Acetaminophen in Patients Undergoing Laparoscopic Cholecystectomy in Japan

Hideki Taniguchi1,Masaki Takenouchi1,Masaharu Imaura1,Mari Nagahuchi2,Hideki Tachibana2,Takaaki Kamada2,Tomoyuki Sato2,Kan Handa3, Tomohisa Egawa3

1Perioperative Support Center, Saiseikai Yokohama-shi Tobu Hospital

2Department of Anesthesiology, Saiseikai Yokohama-shi Tobu Hospital

3Department of Gastrointestinal Surgery, Saiseikai Yokohama-shi Tobu Hospital

Corresponding Author: JOsamu Nishida, Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-Cho, Toyoake-city, Aichi, 470-1192, Japan, Tel: +81-562-93-9008; 
E-Mail[email protected]

Received Date: 30 Dec 2017
Accepted Date: 09 Jan 2018   
Published Date: 12 Jan 2018

Copyright  ©2018 Taniguchi H

Citation: Taniguchi H, Takenouchi M, Imaura M, Nagahuchi M, et al. (2018). Postoperative Scheduled Intravenous Acetaminophen in Patients Undergoing Laparoscopic Cholecystectomy in Japan. M J Anes. 2(1): 009.


Background: This study aimed to assess the economic burden and effect of scheduled intravenous acetaminophen (SIVA) on the analgesic activity in patients undergoing laparoscopic cholecystectomy (LC) following our hospital"s management protocol.

MethodsPatients undergoing LC were enrolled prospectively and consecutively, and managed using the old protocol (Group C), and managed following the new protocol using SIVA (Group S). The primary outcome was postoperative pain assessment estimated by the Numerical Rating Scale (NRS) on a postoperative day 1. Secondary outcomes were the number of rescue medicines and the length of hospitalization (LOH).

Results: The NRS was lower in group S than in group C (group S; 1.0 [0,0–2.75,8.0] vs. group C; 4.0 [0,05.75,6.0]: P < .0001). The number of rescue medicines was lower in group S compared to group C (0 [0,0-0,3.0] vs. 1.0 [0,0-2.25,5.0]: P < .0001). LOH after surgery was also shorter in group S than in group C (3.0 [3.0,3.0-3.0,7.0] days vs. 3.0 [3.0,3.0-3.0,12.0] days: P = 0.0462)

Conclusions: : Introduction of SIVA into the postoperative pain management protocol of LC reduced the postoperative NRS, the number of rescue medicines and the LOH. We recommend the standardization of postoperative pain management in clinical management protocols in Japan.


Scheduled Intravenous Acetaminophen; Acetaminophen; Postoperative Pain Laparoscopic Cholecystectomy; Clinical Management Protocols Enhanced Recovery After Surgery (ERAS).


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