Mathews Journal of Veterinary Science

2572-6579

Previous Issues Volume 3, Issue 1 - 2018

Research Article Full-Text  PDF  

CCl4 Induced Liver Fibrosis Model in Cynomolgus Monkeys

Shanshan Ding*1 , Changqing Zhang1 , Li Zhang2 , Lei Le1 , Xin Zhang3 , Joyce Hwa2 , Tiansheng Zhou4 , Shoutao Liu1 , Zhihai Li1

1 DMPK-PD department, WuXi AppTec, Wuzhong District, Suzhou, Jiangsu Province, China.

2 WuXi AppTec / XenoBiotic Laboratories, 107 Morgan Lane, Plainsboro, New Jersey 08536.

3 DMPK-PD department, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, China.

4 Pathology department, WuXi AppTec, Wuzhong District, Suzhou, Jiangsu Province, China.

Corresponding Author: Shanshan Ding, WuXi AppTec, Wuzhong District, Suzhou, Jiangsu Province, China, Tel: + 8651266374713; Email: ding_shanshan@wuxiapptec.com

Received Date: 22 May 2018
Accepted Date: 20 Jun 2018
Published Date: 27 Jun 2018

Copyright © 2018 Ding S

Citation: Ding S, Zhang C, Zhang L, Le L, et all. (2018). CCl4 Induced Liver Fibrosis Model in Cynomolgus Monkeys. M J Vetr. 3(1): 009. Citation: Ding S, Zhang C, Zhang L, Le L, et all. (2018). CCl4 Induced Liver Fibrosis Model in Cynomolgus Monkeys. Mathews J Vet Sci. 3(1): 009.

 

ABSTRACT

Liver fibrosis is the final common stage of the most chronic liver diseases, it is caused by several factors which lead to a major worldwide health care burden. Over the decades, the understanding of the liver fibrosis disease was growing rapidly, several studies reported that this progress could be regressed or reversed, which give us a bright prospect in developing anti-fibrotic therapies. In this experiment, liver fibrosis was fully developed after CCl4 induction for 7 weeks in eight animals. Clinical pathologic parameters, four indicators of hepatic fibrosis in monkey showed similarly changes in human. All animals had liver fibrosis after 1.5 months of CCl4 induction, and liver fibrosis still existed after 9 months recovery periods, the fibrosis stages in most animals had no obvious regression without treatment.

Keywords: Liver Fibrosis; Animal Model; CCl4; Reverse.


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