¹Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, China

²Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, China

³State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, China

*Corresponding Author: Zheng Jiesheng, Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road, Hangzhou, Zhejiang, 310003, China.

# Chai ZH and Tao R contributed equally to this work.

Citation: Chai ZH. (2019). Paraplegia Caused by Systemic Myopericytomas in an AIDS Patient: A Rare Case. Mathews J Case Rep 4(5): 61.

 

ABSTRACT

Background: Myopericytoma is a rare type of perivascular neoplasm that arises from the skin and peripheral soft tissues. Cases associated with AIDS are even rarer.

Case Description: We present a case of a 31-year-old patient who diagnosed AIDS for 3 years and gradually occurred neuropathy for 1 month. The magnetic resonance imaging (MRI) scan showed multifocal lesion along the spinal canal. The patient was finally diagnosed as systemic myopericytomas. Histopathology revealed myopericytomas. Immunochemistry revealed smooth muscle actin (SMA), Epstein-Barr virus encoded small RNA (EBER) and caldesmon were all positive. Meanwhile, the staining of desmin, S-100 protein, CD34, pancytokeratin (CK-pan) were negative. High-throughput genetic test revealed EBV infection in the tumor tissue. The patient has no evidence of recurrence 9 months after surgery.

Conclusion: The myopericytomas in spinal canal was relatively rare. The case we report is the most multifocal tumor to date. Surgery maybe the only treatment and it was reported that EBV may be related to the occurrence of myopericytomas.

 

Keywords: Spinal canal; Myopericytoma; AIDS; EBV.

 

Abbreviations: MRI: Magnetic resonance imaging; SMA: smooth muscle actin, EBER: Epstein-Barr virus encoded small RNA; CK-pan: pancytokeratin; EBV: Epstein-Barr virus; HMB-45: human melanoma black-45; EMA: epithelial membrane antigen; HHV8: human herpes virus 8.